Wendy Williams is trying to get answers about a potential change in a very serious medical condition … but she says her doctor and her guardian are keeping her in the dark.

Wendy tells TMZ … the medication she takes for a thyroid condition related to Graves’ disease was recently changed and no one will tell her why or answer her questions.

WW says the nurse came in recently with a different color pill and nobody has said a thing … and she’s trying like hell to find out if her thyroid condition is better or worse.

She tells us she’s tried to call her doctor but can’t get through … and since Sunday, she’s been asking her guardian to get in touch with her doctor and let her know if something’s changed with her thyroid issue … but she hasn’t heard back.

Wendy says she’s waiting around for an answer as she sits locked away on the 5th floor of her assisted-living facility — which she likes to refer to as a “luxury prison” — telling us she keeps wondering, “Am I in medical trouble?!?”

Frankly, it all sounds pretty stressful.